Pd(0)-Catalyzed methyl transfer on nucleosides and oligonucleotides, envisaged as a PET tracer.
نویسندگان
چکیده
The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under "ligandless" conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in a few minutes and quantitative yield, even under dilute conditions, thus affording a rapid and efficient new method for oligonucleotide labelling with carbon-11.
منابع مشابه
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ورودعنوان ژورنال:
- Molecules
دوره 18 11 شماره
صفحات -
تاریخ انتشار 2013